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BDBM50308690 CHEMBL605196::N-{1-[(6-Chloropyridin-3-yl)carbonyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

SMILES: FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(Cl)nc1)S(=O)(=O)c1ccccc1

InChI Key: InChIKey=PVSIUMMRWKXDQI-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50308690   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Secreted frizzled-related protein 1


(Homo sapiens (Human))
BDBM50308690
PNG
(CHEMBL605196 | N-{1-[(6-Chloropyridin-3-yl)carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(Cl)nc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H21ClF3N3O5S2/c25-22-9-6-16(15-29-22)23(32)31-12-10-17(11-13-31)30-38(35,36)21-14-19(7-8-20(21)24(26,27)28)37(33,34)18-4-2-1-3-5-18/h1-9,14-15,17,30H,10-13H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of fluorescence probe compound from human SFRP1 after 30 mins by fluorescence polarization assay


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens (Human))
BDBM50308690
PNG
(CHEMBL605196 | N-{1-[(6-Chloropyridin-3-yl)carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(Cl)nc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H21ClF3N3O5S2/c25-22-9-6-16(15-29-22)23(32)31-12-10-17(11-13-31)30-38(35,36)21-14-19(7-8-20(21)24(26,27)28)37(33,34)18-4-2-1-3-5-18/h1-9,14-15,17,30H,10-13H2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 140n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair