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BDBM50308915 3-[2-{[(1-Naphthylmethyl)amino]carbonyl}-4-(1Hpyrazol-1-ylmethyl)phenyl]propanoic aci::CHEMBL603059

SMILES: OC(=O)CCc1ccc(Cn2cccn2)cc1C(=O)NCc1ccc2ccccc2c1

InChI Key: InChIKey=PHRWNJZNMCODSA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308915   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM50308915
PNG
(3-[2-{[(1-Naphthylmethyl)amino]carbonyl}-4-(1Hpyra...)
Show SMILES OC(=O)CCc1ccc(Cn2cccn2)cc1C(=O)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H23N3O3/c29-24(30)11-10-21-9-7-19(17-28-13-3-12-27-28)15-23(21)25(31)26-16-18-6-8-20-4-1-2-5-22(20)14-18/h1-9,12-15H,10-11,16-17H2,(H,26,31)(H,29,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...


Bioorg Med Chem 18: 80-90 (2010)


Article DOI: 10.1016/j.bmc.2009.11.023
BindingDB Entry DOI: 10.7270/Q24X57X2
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM50308915
PNG
(3-[2-{[(1-Naphthylmethyl)amino]carbonyl}-4-(1Hpyra...)
Show SMILES OC(=O)CCc1ccc(Cn2cccn2)cc1C(=O)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H23N3O3/c29-24(30)11-10-21-9-7-19(17-28-13-3-12-27-28)15-23(21)25(31)26-16-18-6-8-20-4-1-2-5-22(20)14-18/h1-9,12-15H,10-11,16-17H2,(H,26,31)(H,29,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...


Bioorg Med Chem 18: 80-90 (2010)


Article DOI: 10.1016/j.bmc.2009.11.023
BindingDB Entry DOI: 10.7270/Q24X57X2
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM50308915
PNG
(3-[2-{[(1-Naphthylmethyl)amino]carbonyl}-4-(1Hpyra...)
Show SMILES OC(=O)CCc1ccc(Cn2cccn2)cc1C(=O)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H23N3O3/c29-24(30)11-10-21-9-7-19(17-28-13-3-12-27-28)15-23(21)25(31)26-16-18-6-8-20-4-1-2-5-22(20)14-18/h1-9,12-15H,10-11,16-17H2,(H,26,31)(H,29,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 520n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...


Bioorg Med Chem 18: 80-90 (2010)


Article DOI: 10.1016/j.bmc.2009.11.023
BindingDB Entry DOI: 10.7270/Q24X57X2
More data for this
Ligand-Target Pair