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BDBM50309000 CHEMBL589819::N-((5'-chloro-3,3'-difluoro-2'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1-ethyl-2-(3-methoxyisoxazole-5-carbonyl)hydrazinecarboxamide

SMILES: CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1

InChI Key: InChIKey=AGCQXBIRJFMROF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50309000   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50309000
PNG
(CHEMBL589819 | N-((5'-chloro-3,3'-difluoro-2'-(5-m...)
Show SMILES CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C24H21ClF2N6O5/c1-4-33(30-23(34)19-10-20(36-3)31-38-19)24(35)28-11-14-6-5-13(7-17(14)26)16-8-15(25)9-18(27)21(16)22-29-12(2)37-32-22/h5-10H,4,11H2,1-3H3,(H,28,35)(H,30,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.430n/an/an/an/an/an/a



Jerini AG

Curated by ChEMBL


Assay Description
Antagonist activity at bradikinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization


Bioorg Med Chem Lett 20: 1225-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.119
BindingDB Entry DOI: 10.7270/Q27P8ZH1
More data for this
Ligand-Target Pair