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BDBM50309022 CHEMBL596717::N-(2-((5'-chloro-3,3'-difluoro-2'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methylamino)-4,5-dimethyl-1H-imidazol-1-yl)-3-methoxyisoxazole-5-carboxamide

SMILES: COc1cc(on1)C(=O)Nn1c(C)c(C)nc1NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1

InChI Key: InChIKey=IOMRQKCYHOEINE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50309022   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50309022
PNG
(CHEMBL596717 | N-(2-((5'-chloro-3,3'-difluoro-2'-(...)
Show SMILES COc1cc(on1)C(=O)Nn1c(C)c(C)nc1NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C26H22ClF2N7O4/c1-12-13(2)36(33-25(37)21-10-22(38-4)34-40-21)26(31-12)30-11-16-6-5-15(7-19(16)28)18-8-17(27)9-20(29)23(18)24-32-14(3)39-35-24/h5-10H,11H2,1-4H3,(H,30,31)(H,33,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



Jerini AG

Curated by ChEMBL


Assay Description
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1beta assessed as inhibition of DAKD-induced calcium mobilizatio...


Bioorg Med Chem Lett 20: 1229-32 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.120
BindingDB Entry DOI: 10.7270/Q2416X5W
More data for this
Ligand-Target Pair