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BDBM50309307 2-(2-(bis(4-fluorophenyl)methyl)-4-(3-sulfamoylphenyl)thiazol-5-yl)acetic acid::CHEMBL597535

SMILES: NS(=O)(=O)c1cccc(c1)-c1nc(sc1CC(O)=O)C(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key: InChIKey=OYPQQMFNEGYGFY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50309307   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309307
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(3-sulfamoylphe...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1nc(sc1CC(O)=O)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H18F2N2O4S2/c25-17-8-4-14(5-9-17)22(15-6-10-18(26)11-7-15)24-28-23(20(33-24)13-21(29)30)16-2-1-3-19(12-16)34(27,31)32/h1-12,22H,13H2,(H,29,30)(H2,27,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309307
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(3-sulfamoylphe...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1nc(sc1CC(O)=O)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H18F2N2O4S2/c25-17-8-4-14(5-9-17)22(15-6-10-18(26)11-7-15)24-28-23(20(33-24)13-21(29)30)16-2-1-3-19(12-16)34(27,31)32/h1-12,22H,13H2,(H,29,30)(H2,27,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 710n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair