BDBM50309334 (+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one::(-)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one::CHEMBL590078

SMILES Cc1cccc2N3CCNCC3NC(=O)c12

InChI Key InChIKey=RGCZEETYNQZRTH-UHFFFAOYSA-N

Data  6 KI  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50309334   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataKi:  206nMAssay Description:Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataKi:  206nMAssay Description:Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataKi:  2.07E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataKi:  2.08E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataKi:  4.48E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataKi:  4.48E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309334((+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed