BDBM50309343 8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7-a]quinazolin-7(1H)-one::CHEMBL590580

SMILES Cc1cccc2N3CCNCCC3NC(=O)c12

InChI Key InChIKey=IDTOIAGIXRXDMI-UHFFFAOYSA-N

Data  3 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50309343   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309343(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309343(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309343(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Affinity DataKi:  141nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309343(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309343(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309343(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Affinity DataEC50:  61nMAssay Description:Agonist activity at 5HT2C receptor in rat fundusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50309343(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed