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BDBM50309404 2-(4-(4-fluorophenyl)-2-((3'-methoxybiphenyl-2-yl)methyl)thiazol-5-yl)acetic acid::CHEMBL600475

SMILES: COc1cccc(c1)-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1

InChI Key: InChIKey=VPDVRTVLTIGUTA-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50309404   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309404
PNG
(2-(4-(4-fluorophenyl)-2-((3'-methoxybiphenyl-2-yl)...)
Show SMILES COc1cccc(c1)-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-20-7-4-6-17(13-20)21-8-3-2-5-18(21)14-23-27-25(22(31-23)15-24(28)29)16-9-11-19(26)12-10-16/h2-13H,14-15H2,1H3,(H,28,29)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 390n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309404
PNG
(2-(4-(4-fluorophenyl)-2-((3'-methoxybiphenyl-2-yl)...)
Show SMILES COc1cccc(c1)-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-20-7-4-6-17(13-20)21-8-3-2-5-18(21)14-23-27-25(22(31-23)15-24(28)29)16-9-11-19(26)12-10-16/h2-13H,14-15H2,1H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair