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BDBM50309432 2-(4-(biphenyl-4-yl)-2-(phenylamino)thiazol-5-yl)acetic acid::CHEMBL602386

SMILES: OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=CVDQCWFGYGVALA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50309432   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309432
PNG
(2-(4-(biphenyl-4-yl)-2-(phenylamino)thiazol-5-yl)a...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H18N2O2S/c26-21(27)15-20-22(25-23(28-20)24-19-9-5-2-6-10-19)18-13-11-17(12-14-18)16-7-3-1-4-8-16/h1-14H,15H2,(H,24,25)(H,26,27)
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KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309432
PNG
(2-(4-(biphenyl-4-yl)-2-(phenylamino)thiazol-5-yl)a...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H18N2O2S/c26-21(27)15-20-22(25-23(28-20)24-19-9-5-2-6-10-19)18-13-11-17(12-14-18)16-7-3-1-4-8-16/h1-14H,15H2,(H,24,25)(H,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 660n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair