BDBM50310142 5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine::BI-90H6::CHEMBL609039

SMILES CCCNc1nnc(Sc2ncc(s2)[N+]([O-])=O)s1

InChI Key InChIKey=QEQSYHIYQPZYMF-UHFFFAOYSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50310142   

TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50310142(5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadia...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of JNK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50310142(5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadia...)
Affinity DataIC50:  290nMAssay Description:Displacement of biotin-labeled pep-JIP1from JNK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50310142(5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadia...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50310142(5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadia...)
Affinity DataKd:  9.40E+3nMAssay Description:Inhibition of wild-type JNK2 by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50310142(5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadia...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FURINMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50310142(5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadia...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Bacillus anthracis anthrax lethal factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50310142(5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadia...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed