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BDBM50310221 7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)-2-(3-ethoxyphenyl)-pyrazolo[1,5-a]pyrimidine::CHEMBL598116

SMILES: CCOc1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1

InChI Key: InChIKey=YJEPQHOFFLZJEH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50310221   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50310221
PNG
(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Show SMILES CCOc1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1
Show InChI InChI=1S/C25H23F2N3O3/c1-2-31-19-5-3-4-17(12-19)20-14-24-28-11-10-21(30(24)29-20)18-8-9-22(33-25(26)27)23(13-18)32-15-16-6-7-16/h3-5,8-14,16,25H,2,6-7,15H2,1H3
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Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human PDE4D


Bioorg Med Chem Lett 20: 922-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.070
BindingDB Entry DOI: 10.7270/Q2SF2W9S
More data for this
Ligand-Target Pair