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BDBM50310250 3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)-pyrazolo[1,5-a]pyrimidin-2-yl]-N,N-diethylbenzamide::CHEMBL599525

SMILES: CCN(CC)C(=O)c1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1

InChI Key: InChIKey=NGQUPCNAAVXEIT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50310250   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50310250
PNG
(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Show SMILES CCN(CC)C(=O)c1cccc(c1)-c1cc2nccc(-c3ccc(OC(F)F)c(OCC4CC4)c3)n2n1
Show InChI InChI=1S/C28H28F2N4O3/c1-3-33(4-2)27(35)21-7-5-6-19(14-21)22-16-26-31-13-12-23(34(26)32-22)20-10-11-24(37-28(29)30)25(15-20)36-17-18-8-9-18/h5-7,10-16,18,28H,3-4,8-9,17H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human PDE4D


Bioorg Med Chem Lett 20: 922-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.070
BindingDB Entry DOI: 10.7270/Q2SF2W9S
More data for this
Ligand-Target Pair