BDBM50310332 2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine::CHEMBL598293

SMILES COc1ccc(Sc2oc3nc(N)nc(N)c3c2C)cc1OC

InChI Key InChIKey=NCEGDNXACJCNGX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50310332   

TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310332(2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfa...)
Affinity DataIC50: >2.00E+5nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310332(2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfa...)
Affinity DataIC50: >2.00E+5nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310332(2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfa...)
Affinity DataIC50:  3.64E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310332(2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfa...)
Affinity DataIC50:  5.17E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310332(2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfa...)
Affinity DataIC50:  6.66E+4nMAssay Description:Inhibition of rat liver DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310332(2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfa...)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed