BDBM50310392 5S-(+)-[4-(2-piperidin-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol::CHEMBL1087426

SMILES Oc1ccc2C3=C(CCOc2c1)c1ccccc1O[C@H]3c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=UHHJAEWQYDXZDY-PMERELPUSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310392   

TargetEstrogen receptor beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310392(5S-(+)-[4-(2-piperidin-1-ylethoxy)phenyl]-11,12-di...)
Affinity DataIC50:  24nMAssay Description:Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310392(5S-(+)-[4-(2-piperidin-1-ylethoxy)phenyl]-11,12-di...)
Affinity DataIC50:  1.24E+3nMAssay Description:Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310392(5S-(+)-[4-(2-piperidin-1-ylethoxy)phenyl]-11,12-di...)
Affinity DataIC50:  150nMAssay Description:Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17beta-estradiol-induced alkaline phosphatase activity after 3 days by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310392(5S-(+)-[4-(2-piperidin-1-ylethoxy)phenyl]-11,12-di...)
Affinity DataIC50:  4.20nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed