BDBM50310477 4-(1-isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxadiazol-3-amine::CHEMBL1077670

SMILES CC(C)Cn1cc(C)nc1-c1nonc1N

InChI Key InChIKey=VJPQVJGSYWEPEZ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310477   

TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310477(4-(1-isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi:  340nMAssay Description:Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310477(4-(1-isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi:  690nMAssay Description:Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310477(4-(1-isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi: >3.30E+3nMAssay Description:Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310477(4-(1-isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi: >3.30E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed