BDBM50311017 CHEMBL1078178::Momelotinib::N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide::US10112907, Example 00019::US10766894, Compound TABLE 1.4::US11203595, TABLE 1.4::US9469613, CYT-0387

SMILES: O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1

InChI Key: InChIKey=ZVHNDZWQTBEVRY-UHFFFAOYSA-N

Data: 29 IC50  8 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 204 hits for monomerid = 50311017   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Activin receptor type-1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	25	n/a	n/a	n/a	n/a	n/a
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Bone morphogenetic protein receptor type-1A (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	405	1.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	107	19	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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TGF-beta receptor type-1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	205	670	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	155	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek3 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek9 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek9 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	143	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	325	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	252	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	155	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50311017 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair