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BDBM50311361 CHEMBL1077877::N-(1-(3-(2-fluoroethoxy)-4-methoxybenzyl)piperidin-4-yl)benzo[d]oxazol-2-amine

SMILES: COc1ccc(CN2CCC(CC2)Nc2nc3ccccc3o2)cc1OCCF

InChI Key: InChIKey=IGQABOYVCUNLKM-UHFFFAOYSA-N

Data: 4 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50311361   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM50311361
PNG
(CHEMBL1077877 | N-(1-(3-(2-fluoroethoxy)-4-methoxy...)
Show SMILES COc1ccc(CN2CCC(CC2)Nc2nc3ccccc3o2)cc1OCCF
Show InChI InChI=1S/C22H26FN3O3/c1-27-20-7-6-16(14-21(20)28-13-10-23)15-26-11-8-17(9-12-26)24-22-25-18-4-2-3-5-19(18)29-22/h2-7,14,17H,8-13,15H2,1H3,(H,24,25)
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PubMed
487n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Displacement of SST14 from human recombinant SST5 receptor expressed in CHO cells by radioligand binding assay


Bioorg Med Chem Lett 19: 6106-13 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.024
BindingDB Entry DOI: 10.7270/Q2PC32H9
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50311361
PNG
(CHEMBL1077877 | N-(1-(3-(2-fluoroethoxy)-4-methoxy...)
Show SMILES COc1ccc(CN2CCC(CC2)Nc2nc3ccccc3o2)cc1OCCF
Show InChI InChI=1S/C22H26FN3O3/c1-27-20-7-6-16(14-21(20)28-13-10-23)15-26-11-8-17(9-12-26)24-22-25-18-4-2-3-5-19(18)29-22/h2-7,14,17H,8-13,15H2,1H3,(H,24,25)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Displacement of SST14 from human recombinant SST2 receptor


Bioorg Med Chem Lett 19: 6106-13 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.024
BindingDB Entry DOI: 10.7270/Q2PC32H9
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM50311361
PNG
(CHEMBL1077877 | N-(1-(3-(2-fluoroethoxy)-4-methoxy...)
Show SMILES COc1ccc(CN2CCC(CC2)Nc2nc3ccccc3o2)cc1OCCF
Show InChI InChI=1S/C22H26FN3O3/c1-27-20-7-6-16(14-21(20)28-13-10-23)15-26-11-8-17(9-12-26)24-22-25-18-4-2-3-5-19(18)29-22/h2-7,14,17H,8-13,15H2,1H3,(H,24,25)
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Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Displacement of SST14 from human recombinant SST3 receptor


Bioorg Med Chem Lett 19: 6106-13 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.024
BindingDB Entry DOI: 10.7270/Q2PC32H9
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50311361
PNG
(CHEMBL1077877 | N-(1-(3-(2-fluoroethoxy)-4-methoxy...)
Show SMILES COc1ccc(CN2CCC(CC2)Nc2nc3ccccc3o2)cc1OCCF
Show InChI InChI=1S/C22H26FN3O3/c1-27-20-7-6-16(14-21(20)28-13-10-23)15-26-11-8-17(9-12-26)24-22-25-18-4-2-3-5-19(18)29-22/h2-7,14,17H,8-13,15H2,1H3,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Displacement of SST14 from human recombinant SST4 receptor


Bioorg Med Chem Lett 19: 6106-13 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.024
BindingDB Entry DOI: 10.7270/Q2PC32H9
More data for this
Ligand-Target Pair