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BDBM50312422 2-(4-((4-(4-(Cyclopentyloxy)phenyl)-5-(4-(trifluoromethoxy)-phenyl)oxazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid::CHEMBL1075683

SMILES: Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2ccc(OC3CCCC3)cc2)ccc1OCC(O)=O

InChI Key: InChIKey=AKKSTCSPKUCDST-UHFFFAOYSA-N

Data: 5 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50312422   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50312422
PNG
(2-(4-((4-(4-(Cyclopentyloxy)phenyl)-5-(4-(trifluor...)
Show SMILES Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2ccc(OC3CCCC3)cc2)ccc1OCC(O)=O
Show InChI InChI=1S/C31H28F3NO7/c1-19-16-25(14-15-26(19)39-18-28(36)37)38-17-27-35-29(20-6-10-23(11-7-20)40-22-4-2-3-5-22)30(41-27)21-8-12-24(13-9-21)42-31(32,33)34/h6-16,22H,2-5,17-18H2,1H3,(H,36,37)
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PubMed
n/an/an/an/a 12n/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta ligand binding domain by FRET assay


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50312422
PNG
(2-(4-((4-(4-(Cyclopentyloxy)phenyl)-5-(4-(trifluor...)
Show SMILES Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2ccc(OC3CCCC3)cc2)ccc1OCC(O)=O
Show InChI InChI=1S/C31H28F3NO7/c1-19-16-25(14-15-26(19)39-18-28(36)37)38-17-27-35-29(20-6-10-23(11-7-20)40-22-4-2-3-5-22)30(41-27)21-8-12-24(13-9-21)42-31(32,33)34/h6-16,22H,2-5,17-18H2,1H3,(H,36,37)
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Article
PubMed
n/an/an/an/a 4n/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50312422
PNG
(2-(4-((4-(4-(Cyclopentyloxy)phenyl)-5-(4-(trifluor...)
Show SMILES Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2ccc(OC3CCCC3)cc2)ccc1OCC(O)=O
Show InChI InChI=1S/C31H28F3NO7/c1-19-16-25(14-15-26(19)39-18-28(36)37)38-17-27-35-29(20-6-10-23(11-7-20)40-22-4-2-3-5-22)30(41-27)21-8-12-24(13-9-21)42-31(32,33)34/h6-16,22H,2-5,17-18H2,1H3,(H,36,37)
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Article
PubMed
n/an/an/an/a 9n/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at mouse PPARdelta by FRET assay


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50312422
PNG
(2-(4-((4-(4-(Cyclopentyloxy)phenyl)-5-(4-(trifluor...)
Show SMILES Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2ccc(OC3CCCC3)cc2)ccc1OCC(O)=O
Show InChI InChI=1S/C31H28F3NO7/c1-19-16-25(14-15-26(19)39-18-28(36)37)38-17-27-35-29(20-6-10-23(11-7-20)40-22-4-2-3-5-22)30(41-27)21-8-12-24(13-9-21)42-31(32,33)34/h6-16,22H,2-5,17-18H2,1H3,(H,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50312422
PNG
(2-(4-((4-(4-(Cyclopentyloxy)phenyl)-5-(4-(trifluor...)
Show SMILES Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2ccc(OC3CCCC3)cc2)ccc1OCC(O)=O
Show InChI InChI=1S/C31H28F3NO7/c1-19-16-25(14-15-26(19)39-18-28(36)37)38-17-27-35-29(20-6-10-23(11-7-20)40-22-4-2-3-5-22)30(41-27)21-8-12-24(13-9-21)42-31(32,33)34/h6-16,22H,2-5,17-18H2,1H3,(H,36,37)
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PubMed
n/an/an/an/a 910n/an/an/an/a



The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair