BDBM50312520 6-(((3S,4S)/(3R,4R)-4-(2-(2-Fluoro-2-(3-fluorophenyl)propylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine::CHEMBL1086858

SMILES Cc1cc(N)nc(CC2CNCC2OCCNCC(F)c2cccc(F)c2)c1

InChI Key InChIKey=NOLWAWWUERSXHH-UHFFFAOYSA-N

Data  3 KI  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50312520   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50312520(6-(((3S,4S)/(3R,4R)-4-(2-(2-Fluoro-2-(3-fluorophen...)
Affinity DataKi:  36nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as formation of nitric oxide by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50312520(6-(((3S,4S)/(3R,4R)-4-(2-(2-Fluoro-2-(3-fluorophen...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as formation of nitric oxide by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50312520(6-(((3S,4S)/(3R,4R)-4-(2-(2-Fluoro-2-(3-fluorophen...)
Affinity DataKi:  3.60E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as formation of nitric oxide by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50312520(6-(((3S,4S)/(3R,4R)-4-(2-(2-Fluoro-2-(3-fluorophen...)
Affinity DataIC50:  310nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as formation of nitric oxide by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50312520(6-(((3S,4S)/(3R,4R)-4-(2-(2-Fluoro-2-(3-fluorophen...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of nNOS in HEK293T cells assessed as nitrite formationMore data for this Ligand-Target Pair