BDBM50312668 CHEMBL1076638::Chemocoxib A (12)::N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide

SMILES: Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)NCCCCNC(=O)CCC(=O)O[C@@H]4c5cc6c(cc5[C@@H]([C@H]7[C@H]4COC7=O)c8cc(c(c(c8)OC)OC)OC)OCO6

InChI Key: InChIKey=VWODTBOQFNUCFF-UHFFFAOYSA-N

Data: 11 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50312668   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase 1 (Sheep)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Sheep)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 [18-504,V335L] (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 [18-604,V509I] (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 [18-604,S516A] (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 [18-604,R106Q] (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 [18-604,Y541F] (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Sheep)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mouse)	BDBM50312668 (N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair