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BDBM50313007 3-(1-methyl-1H-indol-3-yl)-4-(pyridin-3-yl)-1H-pyrrole-2,5-dione::CHEMBL1087380

SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2cccnc2)c2ccccc12

InChI Key: InChIKey=VFTQJAGTZBWUJS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50313007   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50313007
PNG
(3-(1-methyl-1H-indol-3-yl)-4-(pyridin-3-yl)-1H-pyr...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccnc2)c2ccccc12
Show InChI InChI=1S/C18H13N3O2/c1-21-10-13(12-6-2-3-7-14(12)21)16-15(17(22)20-18(16)23)11-5-4-8-19-9-11/h2-10H,1H3,(H,20,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Roche Palo Alto

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...


Bioorg Med Chem Lett 20: 1693-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.038
BindingDB Entry DOI: 10.7270/Q2ZK5HNS
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50313007
PNG
(3-(1-methyl-1H-indol-3-yl)-4-(pyridin-3-yl)-1H-pyr...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccnc2)c2ccccc12
Show InChI InChI=1S/C18H13N3O2/c1-21-10-13(12-6-2-3-7-14(12)21)16-15(17(22)20-18(16)23)11-5-4-8-19-9-11/h2-10H,1H3,(H,20,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Roche Palo Alto

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha


Bioorg Med Chem Lett 20: 1693-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.038
BindingDB Entry DOI: 10.7270/Q2ZK5HNS
More data for this
Ligand-Target Pair