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BDBM50313212 4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid[5-(3,4-dichloro-pheny)-pyridin-2-yl]-amide::CHEMBL1080509

SMILES: OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1ccc(cn1)-c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=QBOFYMDFWGEMON-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50313212   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E synthase


(Homo sapiens (Human))
BDBM50313212
PNG
(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Show SMILES OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1ccc(cn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H13Cl2N3O4S/c21-14-7-5-11(9-15(14)22)12-6-8-17(23-10-12)24-20(27)18-19(26)13-3-1-2-4-16(13)30(28,29)25-18/h1-10,25-26H,(H,23,24,27)
PDB
MMDB

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PC sid
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Similars

Article
PubMed
n/an/a 6.56E+4n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISA


Bioorg Med Chem Lett 20: 1604-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.060
BindingDB Entry DOI: 10.7270/Q25X292V
More data for this
Ligand-Target Pair