BDBM50313352 6-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide::CHEMBL1080881::US9150519, 1-39

SMILES CN(C1CCCCC1)c1cc(ncn1)C(=O)Nc1cc2cn[nH]c2cc1C

InChI Key InChIKey=HIRJAQVDBPWMCT-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313352   

TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM50313352(6-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol...)
Affinity DataEC50:  211nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM50313352(6-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol...)
Affinity DataEC50:  211nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM50313352(6-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol...)
Affinity DataEC50:  2.33E+3nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...More data for this Ligand-Target Pair
In DepthDetails US Patent