BDBM50314192 (+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(4-(pyridin-2-yl)piperidin-1-yl)propan-2-ol::CHEMBL1089289

SMILES CS(=O)(=O)N1CCc2c(C1)c(nn2CC(O)CN1CCC(CC1)c1ccccn1)-c1ccc(c(SCCN2CCCCC2)c1)C(F)(F)F

InChI Key InChIKey=FLVUGMGNWRQWAO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314192   

TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314192((+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-y...)
Affinity DataIC50:  62nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of invariant chain p10 fragment after 24 hrs by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314192((+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-y...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cathepsin S by ADAM-28 substrate-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed