BDBM50314218 (S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-1-(2-hydroxy-3-(piperidin-1-yl)propyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-2-oxoacetamide::CHEMBL1089621

SMILES NC(=O)C(=O)N1CCc2c(C1)c(nn2C[C@@H](O)CN1CCCCC1)-c1ccc(c(SCCN2CCC(F)CC2)c1)C(F)(F)F

InChI Key InChIKey=GQALSEVQDWBHFZ-QFIPXVFZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314218   

TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human cathepsin S by ADAM-28 substrate-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as invariant chain-li degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of invariant chain p10 fragment after 24 hrs by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed