BDBM50314242 CHEMBL1090988::rac-2-hydroxy-1-(1-(2-hydroxy-3-(4-(pyridin-2-yl)piperidin-1-yl)propyl)-3-(3-(2-morpholino-2-oxoethylthio)-4-(trifluoromethyl)phenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone

SMILES OCC(=O)N1CCc2c(C1)c(nn2CC(O)CN1CCC(CC1)c1ccccn1)-c1ccc(c(SCC(=O)N2CCOCC2)c1)C(F)(F)F

InChI Key InChIKey=WAWVBVJOBWMYGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314242   

TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314242(CHEMBL1090988 | rac-2-hydroxy-1-(1-(2-hydroxy-3-(4...)
Affinity DataIC50:  160nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of invariant chain p10li after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314242(CHEMBL1090988 | rac-2-hydroxy-1-(1-(2-hydroxy-3-(4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus expression sytem after 15 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed