BDBM50314759 2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-cyclopenta[e]pyrazolo[1,5-a]pyrimidine::CHEMBL1091206::US8629154, 1.1(1)
SMILES CSc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
InChI Key InChIKey=HNKMZOVFZLBOBK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50314759
Affinity DataKi: 0.458nM ΔG°: -12.9kcal/mole IC50: 0.986nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
Affinity DataKi: 0.458nMAssay Description:Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Chemical Diversity Research Institute
Curated by ChEMBL
Chemical Diversity Research Institute
Curated by ChEMBL
Affinity DataIC50: 118nMAssay Description:Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alphaME-5-HT-induced cAMP accumulation pretreated for 15 secs b...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human 5HT6 receptor in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation pretreated for 15 mins befor...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Compounds of general formulas 1 and 2 were tested for their ability to prevent 5-HT6 receptors activation by serotonin. HEK 293 cells (cells of human...More data for this Ligand-Target Pair