BDBM50315213 2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1H-benzimidazole::4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine::CHEMBL586702::TCMDC-137004
SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
InChI Key InChIKey=HGVNLRPZOWWDKD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 98 hits for monomerid = 50315213
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 0.0160nMAssay Description:Inhibition of p110 alpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 0.0440nMAssay Description:Inhibition of p110 beta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3K-delta (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human PI3Kgamma expressed in baculovirus infected Sf21 insect cells by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Michigan
Curated by ChEMBL
University of Michigan
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PI3Kdelta by TR-FRET based Adapta assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Palermo
Curated by ChEMBL
University of Palermo
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3K p110gamma/p85alpha (unknown origin) assessed as reduction in PIP2 to PIP3 conversion by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of p110deltaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Competitive inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant PI3K delta using ethylenediaminetetraacetic and PIP2 as a substrate incubated for 20 mins in presence of ATP by HTRF ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant PI3Kdelta HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Michigan
Curated by ChEMBL
University of Michigan
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human PI3Kalpha by TR-FRET based Adapta assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3K-alpha (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Michigan
Curated by ChEMBL
University of Michigan
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of his-tagged human recombinant PIK3CD/PIK3R1 using substrate PI incubated for 1 hr by Adapta kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3K-beta (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate m...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human PI3KCdelta by non-radiometric ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3K p110 delta in human A549 cell lysate preincubated with compound for 5 mins followed by [gamma-32p]-ATP addition measured after 20 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in Escherichia coli-infected fall armyworm sf21 cells co-expressing p85 by kinase-glo luminescence ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of N-terminal GST-fused full-length human PI3Kalpha (1 to 1068 residues) expressed in baculovirus expression system using PIP2 as substrat...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr in p...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
University of Auckland
Curated by ChEMBL
University of Auckland
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of mouse recombinant PI3K p110alpha expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimagingMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human His-tagged PI3K p110alpha after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of PI3K-delta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human PI3Kbeta by TR-FRET based Adapta assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 1 hr by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant PI3Kalpha by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by H...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant PI3K alpha using ethylenediaminetetraacetic and PIP2 as a substrate incubated for 20 mins in presence of ATP by HTRF ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of p110alphaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Competitive inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Cancer Chemotherapy Center
Curated by ChEMBL
Cancer Chemotherapy Center
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3K p110 beta in human A549 cell lysate preincubated with compound for 5 mins followed by [gamma-32p]-ATP addition measured after 20 m...More data for this Ligand-Target Pair