BDBM50315238 8-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-3,5-difluoro-phenyl]-2-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-quinoxaline::CHEMBL1092925

SMILES CN1CCN(CC1)c1ccc(cn1)-c1cnc2cccc(-c3cc(F)c(CN4CCS(=O)(=O)CC4)c(F)c3)c2n1

InChI Key InChIKey=JVJAREODIMVDGM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50315238   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315238(8-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethy...)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant GST tagged TYK2 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315238(8-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethy...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant GST tagged JAK3 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315238(8-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethy...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315238(8-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethy...)
Affinity DataIC50:  82nMAssay Description:Inhibition of recombinant GST tagged JAK1 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed