BDBM50315240 1-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-2-{4-[3-(3,4,5-trimethoxy-phenyl)-quinoxalin-5-yl]-phenyl}-ethanone::CHEMBL1093468

SMILES COc1cc(cc(OC)c1OC)-c1cnc2cccc(-c3ccc(CC(=O)N4CCS(=O)(=O)CC4)cc3)c2n1

InChI Key InChIKey=GQGMGPZPVHWSRC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50315240   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315240(1-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-2-{4-[...)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant GST tagged JAK1 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315240(1-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-2-{4-[...)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant GST tagged TYK2 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315240(1-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-2-{4-[...)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant GST tagged JAK3 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315240(1-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-2-{4-[...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed