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BDBM50315331 1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methylazetidin-3-amine::CHEMBL1091569

SMILES: CNC1CN(C1)c1ncnc2c3cc(Cl)ccc3oc12

InChI Key: InChIKey=OYMJTEMKKMATMC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50315331   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315331
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methy...)
Show SMILES CNC1CN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C14H13ClN4O/c1-16-9-5-19(6-9)14-13-12(17-7-18-14)10-4-8(15)2-3-11(10)20-13/h2-4,7,9,16H,5-6H2,1H3
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KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 76n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315331
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methy...)
Show SMILES CNC1CN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C14H13ClN4O/c1-16-9-5-19(6-9)14-13-12(17-7-18-14)10-4-8(15)2-3-11(10)20-13/h2-4,7,9,16H,5-6H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair