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BDBM50315343 (R)-1-(8-chloro-2-(trifluoromethyl)benzofuro[3,2-d]pyrimidin-4-yl)-N-methylpyrrolidin-3-amine::CHEMBL1092543

SMILES: CN[C@@H]1CCN(C1)c1nc(nc2c3cc(Cl)ccc3oc12)C(F)(F)F

InChI Key: InChIKey=WBBJYCNZUHEQHO-IMWMWJONNA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50315343   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315343
PNG
((R)-1-(8-chloro-2-(trifluoromethyl)benzofuro[3,2-d...)
Show SMILES CN[C@@H]1CCN(C1)c1nc(nc2c3cc(Cl)ccc3oc12)C(F)(F)F
Show InChI InChI=1/C16H14ClF3N4O/c1-21-9-4-5-24(7-9)14-13-12(22-15(23-14)16(18,19)20)10-6-8(17)2-3-11(10)25-13/h2-3,6,9,21H,4-5,7H2,1H3/t9-/s2
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Article
PubMed
n/an/a 1.42E+4n/an/an/an/an/an/a



Argenta Discovery Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair