BDBM50315658 2-(4-chloro-6-(2,3-dihydro-1H-inden-5-ylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid::CHEMBL1089158

SMILES OC(=O)C(Sc1nc(Cl)cc(Nc2ccc3CCCc3c2)n1)c1cccc2ccccc12

InChI Key InChIKey=VNPBXBNWSYMQTB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50315658   

TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315658(2-(4-chloro-6-(2,3-dihydro-1H-inden-5-ylamino)pyri...)
Affinity DataEC50:  6.80E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315658(2-(4-chloro-6-(2,3-dihydro-1H-inden-5-ylamino)pyri...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315658(2-(4-chloro-6-(2,3-dihydro-1H-inden-5-ylamino)pyri...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed