BDBM50315668 ((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone::CHEMBL1089485

SMILES C[C@H]1CN(C[C@@H](C)[C@]1(O)c1ccccc1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(F)cc1F)c1ncccn1

InChI Key InChIKey=WAAMCZYAPJAPAO-HCCOPHJMSA-N

Data  1 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50315668   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315668(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315668(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)...)
Affinity DataEC50:  243nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315668(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315668(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)...)
Affinity DataEC50: >2.67E+4nMAssay Description:Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315668(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)...)
Affinity DataEC50: >1.11E+4nMAssay Description:Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed