BDBM50315769 3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea::4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine::CHEMBL1090479::GSK-1070916

SMILES: CCn1cc(c(n1)-c1ccc(NC(=O)N(C)C)cc1)-c1ccnc2[nH]c(cc12)-c1cccc(CN(C)C)c1

InChI Key: InChIKey=QTBWCSQGBMPECM-UHFFFAOYSA-N

Data: 8 KI  19 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 50315769   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.0120	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.0460	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.118	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Ferrochelatase, mitochondrial [R115L] (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase SIK1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.0200	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase SIK1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Targeting protein for Xklp2 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase SIK1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B/Inner centromere protein (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C/Inner centromere protein (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Targeting protein for Xklp2 (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50315769 (GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...) Show SMILES Show InChI	GoogleScholar	UniChem		492	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair