BDBM50316097 3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline::CHEMBL1093532

SMILES Cc1nc2c(cccc2nc1-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O)C(F)(F)F

InChI Key InChIKey=YKGVGRQMFLSEFJ-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50316097   

TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316097(3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(t...)
Affinity DataIC50: 53nMAssay Description:Displacement of [3H]T0901317 from human LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316097(3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(t...)
Affinity DataEC50:  580nMAssay Description:Agonist activity at human LXRbeta in HEK293 cells assessed as Gal4 transactivationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316097(3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(t...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant LXRalpha ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316097(3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(t...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]T0901317 from human LXRalpha ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316097(3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(t...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant LXRbeta ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316097(3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(t...)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at human LXRalpha in HEK293 cells assessed as Gal4 transactivationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed