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BDBM50316377 (R,S)-6-(2-amino-2-carboxyethyl)-3-hydroxypyridazine 1-oxide::CHEMBL1094977

SMILES: NC(Cc1ccc(=O)[nH][n+]1[O-])C(O)=O

InChI Key: InChIKey=JIGIMLJTWNZFQN-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316377   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA1


(HUMAN)
BDBM50316377
PNG
((R,S)-6-(2-amino-2-carboxyethyl)-3-hydroxypyridazi...)
Show SMILES NC(Cc1ccc(=O)[nH][n+]1[O-])C(O)=O
Show InChI InChI=1S/C7H9N3O4/c8-5(7(12)13)3-4-1-2-6(11)9-10(4)14/h1-2,5H,3,8H2,(H,9,11)(H,12,13)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 258n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes


Bioorg Med Chem 18: 1381-7 (2010)


Article DOI: 10.1016/j.bmc.2009.12.072
BindingDB Entry DOI: 10.7270/Q27W6CB2
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50316377
PNG
((R,S)-6-(2-amino-2-carboxyethyl)-3-hydroxypyridazi...)
Show SMILES NC(Cc1ccc(=O)[nH][n+]1[O-])C(O)=O
Show InChI InChI=1S/C7H9N3O4/c8-5(7(12)13)3-4-1-2-6(11)9-10(4)14/h1-2,5H,3,8H2,(H,9,11)(H,12,13)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.16E+4n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at recombinant GluA3 receptor expressed in Xenopus oocytes


Bioorg Med Chem 18: 1381-7 (2010)


Article DOI: 10.1016/j.bmc.2009.12.072
BindingDB Entry DOI: 10.7270/Q27W6CB2
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50316377
PNG
((R,S)-6-(2-amino-2-carboxyethyl)-3-hydroxypyridazi...)
Show SMILES NC(Cc1ccc(=O)[nH][n+]1[O-])C(O)=O
Show InChI InChI=1S/C7H9N3O4/c8-5(7(12)13)3-4-1-2-6(11)9-10(4)14/h1-2,5H,3,8H2,(H,9,11)(H,12,13)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 260n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at recombinant GluA1 receptor expressed in Xenopus oocytes


Bioorg Med Chem 18: 1381-7 (2010)


Article DOI: 10.1016/j.bmc.2009.12.072
BindingDB Entry DOI: 10.7270/Q27W6CB2
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50316377
PNG
((R,S)-6-(2-amino-2-carboxyethyl)-3-hydroxypyridazi...)
Show SMILES NC(Cc1ccc(=O)[nH][n+]1[O-])C(O)=O
Show InChI InChI=1S/C7H9N3O4/c8-5(7(12)13)3-4-1-2-6(11)9-10(4)14/h1-2,5H,3,8H2,(H,9,11)(H,12,13)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.16E+4n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Agonist activity at recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes


Bioorg Med Chem 18: 1381-7 (2010)


Article DOI: 10.1016/j.bmc.2009.12.072
BindingDB Entry DOI: 10.7270/Q27W6CB2
More data for this
Ligand-Target Pair