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BDBM50316659 1-(2-ethoxyethyl)-3-ethyl-5-(4-methylpiperazin-1-yl)-N-(4-methylpyridin-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine::CHEMBL1094211

SMILES: CCOCCn1nc(CC)c2nc(nc(Nc3cc(C)ccn3)c12)N1CCN(C)CC1

InChI Key: InChIKey=GAZBPJSYFHKHNT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50316659   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50316659
PNG
(1-(2-ethoxyethyl)-3-ethyl-5-(4-methylpiperazin-1-y...)
Show SMILES CCOCCn1nc(CC)c2nc(nc(Nc3cc(C)ccn3)c12)N1CCN(C)CC1
Show InChI InChI=1S/C22H32N8O/c1-5-17-19-20(30(27-17)13-14-31-6-2)21(24-18-15-16(3)7-8-23-18)26-22(25-19)29-11-9-28(4)10-12-29/h7-8,15H,5-6,9-14H2,1-4H3,(H,23,24,25,26)
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Similars

Article
PubMed
n/an/a 0.890n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assay


Bioorg Med Chem Lett 20: 3120-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.111
BindingDB Entry DOI: 10.7270/Q2K64K0H
More data for this
Ligand-Target Pair