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BDBM50316775 2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-benzyl-1H-indole-3-yl]ethanamine hydrochloride::CHEMBL1094196

SMILES: COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1

InChI Key: InChIKey=FVGFBWAPMMXCST-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316775   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316775
PNG
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)
Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.960n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50316775
PNG
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)
Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3
PDB
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316775
PNG
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)
Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.80n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50316775
PNG
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)
Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair