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BDBM50316780 4-(2-(3-Amino-9-(5-(4-(dimethylamino)phenyl)pentyl)-2,3,4,9-tetrahydro-1H-tetrahydrocarbazole-6-yloxy)ethyl)-phenol dihydrochloride::CHEMBL3216254

SMILES: Cl.Cl.CN(C)c1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1

InChI Key: InChIKey=DNNFZOSVIGWJPL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316780   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316780
PNG
(4-(2-(3-Amino-9-(5-(4-(dimethylamino)phenyl)pentyl...)
Show SMILES Cl.Cl.CN(C)c1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C33H41N3O2/c1-35(2)27-12-7-24(8-13-27)6-4-3-5-20-36-32-17-11-26(34)22-30(32)31-23-29(16-18-33(31)36)38-21-19-25-9-14-28(37)15-10-25/h7-10,12-16,18,23,26,37H,3-6,11,17,19-22,34H2,1-2H3
PDB

KEGG

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50316780
PNG
(4-(2-(3-Amino-9-(5-(4-(dimethylamino)phenyl)pentyl...)
Show SMILES Cl.Cl.CN(C)c1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C33H41N3O2/c1-35(2)27-12-7-24(8-13-27)6-4-3-5-20-36-32-17-11-26(34)22-30(32)31-23-29(16-18-33(31)36)38-21-19-25-9-14-28(37)15-10-25/h7-10,12-16,18,23,26,37H,3-6,11,17,19-22,34H2,1-2H3
PDB
MMDB

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DrugBank
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316780
PNG
(4-(2-(3-Amino-9-(5-(4-(dimethylamino)phenyl)pentyl...)
Show SMILES Cl.Cl.CN(C)c1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C33H41N3O2/c1-35(2)27-12-7-24(8-13-27)6-4-3-5-20-36-32-17-11-26(34)22-30(32)31-23-29(16-18-33(31)36)38-21-19-25-9-14-28(37)15-10-25/h7-10,12-16,18,23,26,37H,3-6,11,17,19-22,34H2,1-2H3
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50316780
PNG
(4-(2-(3-Amino-9-(5-(4-(dimethylamino)phenyl)pentyl...)
Show SMILES Cl.Cl.CN(C)c1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C33H41N3O2/c1-35(2)27-12-7-24(8-13-27)6-4-3-5-20-36-32-17-11-26(34)22-30(32)31-23-29(16-18-33(31)36)38-21-19-25-9-14-28(37)15-10-25/h7-10,12-16,18,23,26,37H,3-6,11,17,19-22,34H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair