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BDBM50316784 4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydro-1Htetrahydrocarbazole-6-yloxy)ethyl)phenol hydrochloride::CHEMBL1097189

SMILES: NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1

InChI Key: InChIKey=WYTDNCFQYUGZDI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316784   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.90n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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PC sid
UniChem

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Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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UniChem

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Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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GoogleScholar
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair