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BDBM50317939 3-(3-(2-benzyl-4-methyl-1-phenethyl-1H-imidazol-5-yl)phenyl)-N-hydroxyacrylamide::CHEMBL1094094

SMILES: Cc1nc(Cc2ccccc2)n(CCc2ccccc2)c1-c1cccc(\C=C\C(=O)NO)c1

InChI Key: InChIKey=VINFAVNHTFQZFB-FOCLMDBBSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50317939   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50317939
PNG
(3-(3-(2-benzyl-4-methyl-1-phenethyl-1H-imidazol-5-...)
Show SMILES Cc1nc(Cc2ccccc2)n(CCc2ccccc2)c1-c1cccc(\C=C\C(=O)NO)c1
Show InChI InChI=1S/C28H27N3O2/c1-21-28(25-14-8-13-24(19-25)15-16-27(32)30-33)31(18-17-22-9-4-2-5-10-22)26(29-21)20-23-11-6-3-7-12-23/h2-16,19,33H,17-18,20H2,1H3,(H,30,32)/b16-15+
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Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC2


Bioorg Med Chem Lett 20: 3138-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.092
BindingDB Entry DOI: 10.7270/Q2514058
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50317939
PNG
(3-(3-(2-benzyl-4-methyl-1-phenethyl-1H-imidazol-5-...)
Show SMILES Cc1nc(Cc2ccccc2)n(CCc2ccccc2)c1-c1cccc(\C=C\C(=O)NO)c1
Show InChI InChI=1S/C28H27N3O2/c1-21-28(25-14-8-13-24(19-25)15-16-27(32)30-33)31(18-17-22-9-4-2-5-10-22)26(29-21)20-23-11-6-3-7-12-23/h2-16,19,33H,17-18,20H2,1H3,(H,30,32)/b16-15+
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PC sid
UniChem

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Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC8


Bioorg Med Chem Lett 20: 3138-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.092
BindingDB Entry DOI: 10.7270/Q2514058
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50317939
PNG
(3-(3-(2-benzyl-4-methyl-1-phenethyl-1H-imidazol-5-...)
Show SMILES Cc1nc(Cc2ccccc2)n(CCc2ccccc2)c1-c1cccc(\C=C\C(=O)NO)c1
Show InChI InChI=1S/C28H27N3O2/c1-21-28(25-14-8-13-24(19-25)15-16-27(32)30-33)31(18-17-22-9-4-2-5-10-22)26(29-21)20-23-11-6-3-7-12-23/h2-16,19,33H,17-18,20H2,1H3,(H,30,32)/b16-15+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC6


Bioorg Med Chem Lett 20: 3138-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.092
BindingDB Entry DOI: 10.7270/Q2514058
More data for this
Ligand-Target Pair