BDBM50318131 (14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-10,15,17-triazatetracyclo[13.5.3.1^{3,7}.0^{18,22}]tetracosa-1(21),3(24),4,6,16,18(22),19-heptaen-11-one::CHEMBL1095429

SMILES NC1=Nc2cc(F)c3Oc4cccc(CCN(C5CCCCC5)C(=O)CC[C@@H](C5CCCCC5)N1Cc2c3)c4

InChI Key InChIKey=MEJGMIGRSQIMGB-LJAQVGFWSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50318131   

TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318131((14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-...)
Affinity DataKi:  8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318131((14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed