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BDBM50318168 CHEMBL1097368::N-1H-indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

SMILES: C(Cc1ccccc1)c1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2[nH]1

InChI Key: InChIKey=PWLPHODRHOUKAZ-UHFFFAOYSA-N

Data: 4 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318168   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50318168
PNG
(CHEMBL1097368 | N-1H-indol-5-yl-6-(2-phenylethyl)-...)
Show SMILES C(Cc1ccccc1)c1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2[nH]1
Show InChI InChI=1S/C22H19N5/c1-2-4-15(5-3-1)6-7-18-13-19-21(24-14-25-22(19)27-18)26-17-8-9-20-16(12-17)10-11-23-20/h1-5,8-14,23H,6-7H2,(H2,24,25,26,27)
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Article
PubMed
n/an/a 5.61E+4n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 20: 3177-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.064
BindingDB Entry DOI: 10.7270/Q23R0T2Z
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50318168
PNG
(CHEMBL1097368 | N-1H-indol-5-yl-6-(2-phenylethyl)-...)
Show SMILES C(Cc1ccccc1)c1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2[nH]1
Show InChI InChI=1S/C22H19N5/c1-2-4-15(5-3-1)6-7-18-13-19-21(24-14-25-22(19)27-18)26-17-8-9-20-16(12-17)10-11-23-20/h1-5,8-14,23H,6-7H2,(H2,24,25,26,27)
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PubMed
n/an/a 1.04E+5n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 20: 3177-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.064
BindingDB Entry DOI: 10.7270/Q23R0T2Z
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50318168
PNG
(CHEMBL1097368 | N-1H-indol-5-yl-6-(2-phenylethyl)-...)
Show SMILES C(Cc1ccccc1)c1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2[nH]1
Show InChI InChI=1S/C22H19N5/c1-2-4-15(5-3-1)6-7-18-13-19-21(24-14-25-22(19)27-18)26-17-8-9-20-16(12-17)10-11-23-20/h1-5,8-14,23H,6-7H2,(H2,24,25,26,27)
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n/an/a 3.16E+4n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 20: 3177-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.064
BindingDB Entry DOI: 10.7270/Q23R0T2Z
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50318168
PNG
(CHEMBL1097368 | N-1H-indol-5-yl-6-(2-phenylethyl)-...)
Show SMILES C(Cc1ccccc1)c1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2[nH]1
Show InChI InChI=1S/C22H19N5/c1-2-4-15(5-3-1)6-7-18-13-19-21(24-14-25-22(19)27-18)26-17-8-9-20-16(12-17)10-11-23-20/h1-5,8-14,23H,6-7H2,(H2,24,25,26,27)
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n/an/a 2.24E+5n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


Bioorg Med Chem Lett 20: 3177-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.064
BindingDB Entry DOI: 10.7270/Q23R0T2Z
More data for this
Ligand-Target Pair