BDBM50318666 (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-tetrahydrospiro-[beta-carboline-1,3'-indol]-2'(1'H)-one::CHEMBL1082723::NITD609

SMILES: C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc21

InChI Key: InChIKey=CKLPLPZSUQEDRT-UHFFFAOYSA-N

Data: 65 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 50318666   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Neuropeptide Y receptor type 2 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Neuropeptide Y receptor type 1 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Substance-P receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Muscarinic acetylcholine receptor M3 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Muscarinic acetylcholine receptor M2 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Muscarinic acetylcholine receptor M1 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Motilin receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Amine oxidase [flavin-containing] A (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Neurotensin receptor type 1 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H3 receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histamine H2 receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histamine H1 receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Growth hormone secretagogue receptor type 1 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glucocorticoid receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Glucagon receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Gastric inhibitory polypeptide receptor (Rat)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Estrogen receptor beta (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Hydroxycarboxylic acid receptor 2 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Sodium-dependent noradrenaline transporter (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Kappa-type opioid receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 2A (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 2B (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 2C (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 3A (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Sodium-dependent serotonin transporter (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Thromboxane A2 receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Vasopressin V1a receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vasopressin V2 receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Type-1 angiotensin II receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-2 adrenergic receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Delta-type opioid receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2B adrenergic receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Melanocortin receptor 3 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Adenosine receptor A2a (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Adenosine receptor A3 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-1 adrenergic receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1A adrenergic receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2A adrenergic receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2C adrenergic receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Androgen receptor (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50318666 (NITD609 | (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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