BDBM50318991 2-((1-(2-hydroxy-3-(2-isopropyl-5-methylphenoxy)propyl)piperidin-4-yl)methyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione::CHEMBL1083994

SMILES CC(C)c1ccc(C)cc1OCC(O)CN1CCC(CN2C(=O)c3cccc4cccc(C2=O)c34)CC1

InChI Key InChIKey=LTIGBEPXXOGOFS-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50318991   

TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50318991(2-((1-(2-hydroxy-3-(2-isopropyl-5-methylphenoxy)pr...)
Affinity DataKi:  80nMAssay Description:Displacement of [125I]cyanopindolol from human adrenergic beta2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50318991(2-((1-(2-hydroxy-3-(2-isopropyl-5-methylphenoxy)pr...)
Affinity DataKi:  411nMAssay Description:Antagonist activity at human adrenergic beta3 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50318991(2-((1-(2-hydroxy-3-(2-isopropyl-5-methylphenoxy)pr...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125I]cyanopindolol from human adrenergic beta-1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50318991(2-((1-(2-hydroxy-3-(2-isopropyl-5-methylphenoxy)pr...)
Affinity DataIC50:  1.47E+3nMAssay Description:Antagonist activity at human adrenergic beta3 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50318991(2-((1-(2-hydroxy-3-(2-isopropyl-5-methylphenoxy)pr...)
Affinity DataIC50:  377nMAssay Description:Antagonist activity at human adrenergic beta1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed