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BDBM50319193 4-Acetylamino-8-Methoxy-3-methyl-1-propyl-imidazo[1,5-a]-pyrido[3,2-e]pyrazine::CHEMBL1083715

SMILES: CCCc1nc(C)c2c(NC(C)=O)nc3ccc(OC)nc3n12

InChI Key: InChIKey=ZZFTYHKMONNQIW-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50319193   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319193
PNG
(4-Acetylamino-8-Methoxy-3-methyl-1-propyl-imidazo[...)
Show SMILES CCCc1nc(C)c2c(NC(C)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H19N5O2/c1-5-6-12-17-9(2)14-15(18-10(3)22)19-11-7-8-13(23-4)20-16(11)21(12)14/h7-8H,5-6H2,1-4H3,(H,18,19,22)
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Similars

Article
PubMed
n/an/a 472n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N
More data for this
Ligand-Target Pair