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BDBM50319308 (+/-)-3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-3-methylphenoxy)-N-((1-methylpiperidin-3-yl)methyl)propan-1-amine::CHEMBL1084354

SMILES: CN1CCCC(CNCCCOc2ccc(-c3nc4ccc(F)c(C)c4[nH]3)c(C)c2)C1

InChI Key: InChIKey=IDIYNCNZIJYGSP-UHFFFAOYNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50319308   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319308
PNG
((+/-)-3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-...)
Show SMILES CN1CCCC(CNCCCOc2ccc(-c3nc4ccc(F)c(C)c4[nH]3)c(C)c2)C1
Show InChI InChI=1/C25H33FN4O/c1-17-14-20(31-13-5-11-27-15-19-6-4-12-30(3)16-19)7-8-21(17)25-28-23-10-9-22(26)18(2)24(23)29-25/h7-10,14,19,27H,4-6,11-13,15-16H2,1-3H3,(H,28,29)
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PC cid
PC sid
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Similars

Article
PubMed
557n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair