BDBM50319558 (R)-ethyl 5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiophene-2-carbimidate::CHEMBL1086534

SMILES CCOC(=N)c1ccc(s1)-c1ccc2cc(CCN3CCC[C@H]3C)ccc2n1

InChI Key InChIKey=FWRAPQVKJFNVCO-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319558   

TargetHistamine H3 receptor(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50319558((R)-ethyl 5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)q...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50319558((R)-ethyl 5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)q...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319558((R)-ethyl 5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)q...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319558((R)-ethyl 5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)q...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319558((R)-ethyl 5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)q...)
Affinity DataIC50: 4.80E+3nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed