BDBM50319621 CHEMBL1086088::N-Ethyl-4-methyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amine

SMILES CCNc1nc(C)c(s1)-c1ccnc(Nc2cc(OC)c(OC)c(OC)c2)n1

InChI Key InChIKey=LNGVCHKMQJKHDR-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50319621   

TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  463nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  564nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  1.22E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed